The Middle East has been rocked by US and Iranian attacks of a scale unseen since an April ceasefire, as fighting over the strategic Strait of Hormuz threatened to derail efforts.
Both sides reported hitting dozens of targets, placing fresh strain on an interim deal to end their war and pushing oil prices to their highest level in two weeks.
Iran closes Strait of Hormuz again over Israel's attacks in Lebanon, accuses US and Israel of violating ceasefire deal.
Israel's military said Friday that it had struck more than 80 Hezbollah targets in Lebanon and killed dozens of members of the Iran-backed group.
"During a period supposedly defined by restraint and protection, a child has been killed, on average, every single day for more than eight months," UNICEF spokesman James Elder said.
Iran has condemned what it calls violations by the United States after its strikes on the southern port city of Bandar Abbas, while vowing to defend its sovereignty.